Goldberg Lab

  • Goldberg Lab

Goldberg Lab

Welcome to the Goldberg Lab

Science Center B307
Phone: +1-856 566-6718
Email: gary.goldberg@rowan.edu

Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. We are interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth, invasion, metastasis, and inflammation.

Publications (since 2020):

  1. Ralph, A.C.L., Valadão, I.C., Cardoso, E.C., Garcilazo, F.S.G., Martins, V.R., Oliveira, L.M.S., Bevilacqua, E.M.A.F., Geraldo, M.V., Jaeger, R.J., Goldberg, G.S., and Freitas, V.M. (2020) Environmental control of mammary carcinoma cell expansion by acidification and spheroid formation in vitro. Nature Scientific Reports. 10, 21959-21970. PMID: 33319820.
  2. Hamilton, K.L., Sheehan, S.A., Retzbach, E.P., Timmerman, C.A., Gianneschi, G.B., Tempera, P.J., Balachandran, P., and Goldberg, G.S. (2021) Effects of Maackia amurensis seed lectin (MASL) on oral squamous cell carcinoma (OSCC) gene expression and transcriptional signaling pathways. Journal of Cancer Research and Clinical Oncology. 147, 445–457. PMID: 33205348.
  3. Sheehan, S.A., Hamilton, K.L., Retzbach, E.P., Balachandran, P., Krishnan, H., Leone, P., Lopez-Gonzalez, M., Suryavanshi, S., Kumar, P., Russo, R., and Goldberg, G.S. (2021) Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progression. Experimental Cell Research. 403, 112594-112560. PMID: 33823179.
  4. Sheehan, S.A., Retzbach, E.P., Shen, Y., Krishnan, H., and Goldberg, G.S. (2022) Heterocellular N-cadherin junctions enable nontransformed cells to inhibit the growth of adjacent transformed cells. Cell Communication and Signaling. 20, 1-17. PMID: 35177067.
  5. Retzbach, E.P., Sheehan, S.A., Krishnan, H., Zheng, H., Zhao, C., and Goldberg, G.S. (2022) Independent effects of Src kinase and podoplanin on anchorage independent cell growth and migration. Molecular Carcinogenesis. 61, 677-689. PMID: 35472679.
  6. Hamilton, K.L, Greenspan, A.A., Shienbaum, A.J., Fischer, B.D., Bottaro, A., and Goldberg, G.S. (2022) Maackia amurensis seed lectin (MASL) ameliorates articular cartilage destruction and increases movement velocity of mice with TNFα induced rheumatoid arthritis. Biochemical and Biophysical Reports. 32, 101341, 1-7. PMID: 36120492.
  7. Hamilton, K.L., Kuo, Y.-C., Horneffer, Stein, T.P., and Goldberg, G.S. (2023) Video didactic preparation augments problem based learning for first year medical students. Journal of Medical Education and Curricular Development. 10, 1-4. PMID: 37275656.
  8. Yin, A.C., Holdcraft, C.J., Brace, E.J., Hellmig, T.J., Basu, S., Parikh, S., Jachimowska, K., Kalyoussef, E., Roden, D., Baredes, S., Capitle, E.M., Suster, D.I., Shienbaum, A.J., Zhao, C., Zheng, H., Balcaen, K., Devos, S., Haustraete, J., Fatahzadeh, M. and Goldberg, G.S. (2024) Maackia amurensis seed lectin (MASL) and soluble human podoplanin (shPDPN) sequence analysis and effects on human oral squamous cell carcinoma (OSCC) cell migration and viability. Biochemical and Biophysical Research Communications. 710, 149881. PMID: 38583233.
  9. Nicoletto, R.E., Holdcraft, C.J., Yin, A.C., Retzbach, E.P., Sheehan, S.A., Greenspan, A.A., Laugier, C.M., Trama, J., Zhao, C., Zheng, H., and Goldberg, G.S. (2024) Effects of cadherin mediated contact normalization on oncogenic Src kinase mediated gene expression and protein phosphorylation. Nature Scientific Reports. 14, 23942. PMID: 39397108.

Books:

Cancer Chemotherapy: Basic Science to the Clinic (2020) Goldberg, G.S. and Airley. R. Goldberg G.S. (Ed) Wiley-Blackwell, John Wiley and Sons, Ltd. ISBN-13: 978-1118963852.

Chapters:

Hellmig, T.J., Brace, E.J., Greenspan, A., Laugier, C., Aradhya, A., Basu, S., Parikh, S., Jachimowska, K., Wu, X., Shen, Y., Hamilton, K.L., and Goldberg, G.S. (2023) Amur maackia (Maackia amurensis) seed lectin history and potential effect on cancer progression, inflammation, and viral infection. In: Rajendram, R., Preedy, V. and Patel, V. (Ed.) Ancient and Traditional Foods, Plants, Herbs and Spices used in Cancer. 89-101. Oxfordshire: Taylor and Francis.

Monographs:

  1. Goldberg, G.S. and Martin-Villar, E. (2022) Molecular Mechanisms of Tumor Development and Progression - A Themed Honorary Issue to Prof. Miguel Quintanilla. Cells.
  2. Fan, S., Parente-Arias, P., Goldberg, G.S., and Ferrone, S. (2022) Immunotherapy and Immune Regulation of Head and Neck Cancer. Frontiers in Oncology.

Invited Presentations (since 2020):

  1. “Fibroblast cadherins control Src kinase induced cell motility and transformed cell morphology” (11/05/2020) Rowan University Virtual Fall Research Retreat. (presented by graduate student Stephanie Sheehan)
  2. “Evidence that video didactic preparation can augment problem-based learning” (04/29/2022) Annual American Association of Colleges of Osteopathic Medicine (AACOM) meeting. Denver CO. (presented by DO student Kelly Hamilton)
  3. “Podoplanin (PDPN) enables transformed cells to migrate and escape growth control mediated by cadherin junctions with adjacent nontransformed cells” (12/05/2022) Cell Bio 2022 - International ASCB/EMBO Meeting, Washington, DC.
  4. “Maackia amurensis seed lectin (MASL) increases movement velocity of mice with TNFα induced rheumatoid arthritis” (12/07/2022) 2022 International PDPN meeting, Alexandria, VA. (presented by medical student Amanda Greenspan)
  5. “Podoplanin expression and ex vivo lectin effects on OSCC cells from clinical trial subjects” (12/07/2022) 2022 International PDPN meeting, Alexandria, VA. (presented by medical student Eamonn Brace)
  6. “Podoplanin (PDPN) enables transformed cells to migrate and escape growth control mediated by cadherin junctions with adjacent nontransformed cells” (12/07/2022) 2022 International PDPN meeting, Alexandria, VA.
  7. “Podoplanin (PDPN) enables transformed cells to migrate and escape growth control mediated by cadherin junctions with adjacent nontransformed cells, and can be targeted to inhibit tumor cell growth and motility” (06/21/2022) Cancer Metabolism and Immunology Program Meeting, Cancer Institute of New Jersey, New Brunswick (Rutgers Zoom).
  8. “War and discovery on the path to cancer chemotherapy” (11/02/2023) MTSU Biology Seminar Series, Middle Tennessee State University, Murfreesboro, TN.
  9. “Podoplanin enables transformed cells to override contact normalization and can be targeted to inhibit OSCC cell viability” (09/21/2024) 83rd Annual Japanese Cancer Association Meeting, Fukuoka International Congress Center, Fukuoka, Japan.
  10. “The podoplanin receptor promotes cell motility and can serve as a chemotherapeutic target downstream of the Src tyrosine kinase” (10/01/2024) New Jersey Medical School, Rutgers University, Newark, NJ.

Contribute to Cancer Research:

The Foundation of Rowan University has established a fund where 100% of donated money will go directly to this research program with no administrative or other deductions. To support the "Goldberg Cancer Research Program" with your tax-deductible charitable contribution, contact Gary Goldberg at 856-566-6718 or at gary.goldberg@rowan.edu.

Biosketch:

Dr. Goldberg is a Professor at Rowan University. He has worked at major institutes around the world to elucidate fundamental mechanisms that control cell behavior and develop approaches to understand and combat cancer. His research has been published in over 70 articles that have been referenced thousands of times, a textbook, and several book chapters. He has invented technology described in several issued patents, has presented at numerous national and international meetings, and run several workshops around the world. He has also founded the pharmaceutical company Sentrimed, the international group PDPN Central to support academic and translational research, and the PBLMed platform to guide medical education. Dr. Goldberg is investigating how growth factor receptors promote tumor cell growth and motility, and developing ways to target these receptors to prevent and combat cancer. His work has led to the generation of compounds supported by the NIH and other agencies with IRB and FDA IND approval for clinical trials aimed to prevent and treat cancer. Dr. Goldberg is working with colleagues at research centers in the USA and other countries to develop these compounds into pharmaceutical reagents that can be used to treat cancer, as well as inflammatory diseases including arthritis.

Relevant Websites:

Google Scholar

www.pdpn.info

www.pblmed.com

www.sentrimed.com

www.youtube.com/watch?v=87MfI7g9oKQ

today.rowan.edu/news/2021/06/rowan-som-begins-human-clinical-trials.html