Research in the laboratory focuses on mechanisms of mitochondrial gene expression and its regulation. We study an array of nuclear DNA encoded protein factors that control the expression of mitochondrial genes.

Our laboratory's research conducts studies involving airway progenitor cell development. 

The Chang lab studies the physiology and pathology of the nervous system. Our research focuses on host-microbe interactions and brain-gut axis signaling.

Focusing on cancer, T-cell acute lymphoblastic leukemia, mouse models of disease, therapeutic delivery strategies, biodevices and coating materials... 

Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. We are interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth, invasion, and metastasis.

My research program studies the molecular mechanisms underlying how the nuclear envelope regulates some of these fundamental cellular processes, including genomic architecture, RNA transcription and cell signaling.

The regulatory pathways associated with tongue homeostasis and genes responsible for taste fungiform papilla/taste bud alteration after HH pathway blockade are not clearly understood and remain challenging to understand tongue physiology in response to therapeutic interventions such as HH signaling blockade.

Our primary research program is focused on understanding the interactions between psychosocial stressor exposure, stress-coping strategies, and the behavioral effects of drugs of abuse.

Our lab is interested in understanding how sleep disorders lead to hypertension and other cardiorespiratory disorders. Specifically, we are interested in the understanding the role different brain regions have in the development of disease. We use a multi-faceted approach that include ex vivo and in vivo techniques to identify and characterize the neural circuity involved in sleep-related disorders.

Our group focuses on mammalian ribosome biogenesis and biochemical pathways that monitor the health of the protein synthesis machinery. We are particularly interested in stress-induced damage to the ribosome and how changes in ribosome homeostasis contribute to human disease.

Research in my laboratory is focused on the ribosome – a complex molecular machine that performs synthesis of polypeptides in living cells.

The primary research focus of my laboratory is to understand the role of the central monoaminergic systems in brain function and behavior. 

Despite advances in antibiotic therapy, there is a significant need for more efficacious treatments of severe bacterial infections. The host responds to bacterial infection by activating the innate immune system to clear pathogen by phagocytic and killing mechanisms...