Research

  • Pestov Lab

Research

Research

Ribosome biogenesis and its links to cancer

To synthesize proteins, cells require functional ribosomes. A typical human cell contains hundreds of thousands of ribosomes and manufactures a similar number of ribosomes with every cell division. Ribosome biogenesis, the process of building new ribosomes, is a complex molecular assembly process that employs hundreds of protein factors and small RNAs. One major interest of our lab is to understand how cells maintain the integrity of ribosome assembly under stress conditions. This is especially important for cancer biology because cells require active ribosome biogenesis to grow and many anticancer drugs directly or indirectly affect ribosome formation.

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